Endocrine Abstracts

Background: Restrictive anorexia nervosa (AN) presents an adaptive appetite regulating profile including mainly high levels of ghrelin. Because this adaptive mechanism is not effective on food intake, other appetite regulating peptides need to be explored. 26RFa is a hypothalamic neuropeptide that stimulates appetite, gonadotropin release and bone metabolism. The aim of the current study was to evaluate circadian levels of 26RFa in AN patients compared with healthy subjects, o...

Energy balance is controlled by the arcuate nucleus through integration of peripheral hormonal signals such as leptin, ghrelin, peptide YY (PYY) and glucagon like peptide 1 (GLP-1). The commonest reason for young women in the developed world to be underweight is restrictive anorexia nervosa (AN). Constitutionally thinness (CT) has been described in young women who satisfies the WHO definition for moderate to severe underweight (BMI 13–16.9 kg/m2). CT women have...

Introduction: Constitutional thinness (CT) is a rare condition of natural low body weight, with normal menstruation, no fear of weight gain and no hormonal abnormalities except for an anorexigenic hormonal profile. CT can be considered as the opposite of obesity and its resistance to weight loss. Therefore, we hypothesised they would have a resistance to weight gain.Methods: 10 female Controls (BMI 18.5–25 kg/m2) and 10 CT women (BMI<...